Implementing high throughput screening and taking advantage of next generation sequencing can greatly aid in drug discovery research and development. However, the process requires considerable planning and research to be effective. In that regard, consider these guidelines for implementing high throughput screening and utilizing next generation sequencing in drug discovery.1. Quantify your needs – Precisely detailing your needs means that you will be able to properly anticipate where equipment should be installed for maximum efficiency and minimum cost.
2. Realistically assess your investment potential – High throughput screening will return your investment through the efficiency it brings and the increased workload you’ll be able to take on. However, you’ll need to assess your resources or face the consequence of exceeding your means.
3. Keep your records straight – Proper boilerplate and detailed paperwork that explicitly outlines your needs, available resources and goals may seem like a costly investment of time, but it will help you realistically set a timeline, identify your limits and establish firm goals for implementation.
4. Research – Look to competitors and compatriots alike to see what has and hasn’t worked for them. Their work can illuminate potential pitfalls you can avoid.
5. Speak with fellows in your field – An inexpensive way to further research high throughput screening and next generation sequencing is to speak with fellows in your field. Their candor, experience and advice are invaluable to you and your work.
6. Speak with vendors – Another benefit of speaking with compatriots is that they’ll be able to recommend vendors who can offer you a good price. Try to work with established vendors to capitalize on the best deals.
7. Conduct tests - Extensive testing should be done on preliminary high throughput screening processes. Involving staff with this early testing will help you focus on initial issues that may arrive.
8. Gather feedback – Work with your team to gather feedback. No matter how familiar you are with the equipment, you’ll inevitably miss out on key points of concern. Your team has extensive first-hand experience on key points of concern that can greatly impact your work.
9. Documentation - Continue proper documentation even after installation is complete. There’s no telling how many years down the line a problem may occur, so it pays to be prepared.
10. Continually refine - No matter how well the installation process went there’s always room for improvement.
High throughput screening and next generation sequencing are both valuable tools. With the proper research, investment and preparation, you’ll continue to reap dividends form your high throughput technologies for years to come.
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